Breakthrough Clinical Trial Offers Hope for Rare Pancreatic Cancer Patients

Allison Lippman Kuban’s journey through a pancreatic cancer diagnosis is a testament to resilience and the power of hope. At just 31 years old, she was thriving in her career as a hotel manager and enjoying a blossoming relationship. However, a persistent pain in her side would lead her down an unexpected path, ultimately revealing a diagnosis that would change her life forever.

Unforeseen Diagnosis

In the busy spring of 2017, Allison began experiencing discomfort on her left side. Initially attributing it to stress, she attempted various home remedies, from hydration to dietary changes, but nothing alleviated her pain. Eventually, she decided to consult her doctor, who ordered a CT scan. To her dismay, the scan didn’t reveal any immediate issues, yet the report contained the alarming term "mass."

• Key Moments:
  • Ignored pain leads to a doctor’s visit.
  • CT scan shows no apparent problems.
  • A troubling term "mass" appears in the report.

Feeling uneasy about her health, Allison sought a second opinion from a gastrointestinal specialist after her doctor prescribed antidepressants, which she declined. The waiting game for a colonoscopy only amplified her discomfort, and the pain intensified to the point of incapacitation.

The Hospital Visit

Rushed to the emergency room by her boyfriend, Eric, and her father, Allison underwent a series of tests, including blood work and an ultrasound. When the ER physician mentioned "lesions on my liver," she was left bewildered, having never encountered such terminology before.

• Immediate Actions:
  • ER visit leads to a series of tests.
  • Diagnosis of liver lesions creates confusion.

The following day, a biopsy confirmed her worst fears: she had neuroendocrine cancer, requiring monthly treatment. Despite the initial optimism, Allison soon learned that the mass on her pancreas was actually acinar cell carcinoma, a rare form of pancreatic cancer.

Seeking a Second Opinion

With the weight of the diagnosis sinking in, Allison turned to UT Southwestern in Dallas for a second opinion, where she met Dr. Shaalan Beg. His compassionate approach provided clarity as he explained her stage IV diagnosis, noting that the cancer had metastasized to her liver and lymph nodes.

• A New Treatment Plan:
  • Chemotherapy every two weeks.
  • Port placement for treatment.

Overwhelmed with emotion, Allison found solace in her family’s support, yet the burden of her illness weighed heavily on her spirit.

Navigating Treatment and Genetic Insights

Allison underwent chemotherapy comprising several powerful drugs. Despite enduring 14 rounds, she faced numerous side effects, including significant weight loss and fatigue. The emotional toll was just as challenging, especially when her young nephew would ask if she felt better.

• Chemotherapy Experience:
  • Multiple medications to manage side effects.
  • The struggle with physical and emotional health.

In a twist of fate, Dr. Beg had her biopsy sent for genetic testing, which revealed a RET fusion mutation. This discovery opened the door to targeted clinical trials.

New Hope Through Clinical Trials

With her mother’s help, Allison contacted MD Anderson in Houston and met with Dr. Vivek Subbiah, who exuded positivity and confidence in a new treatment. Starting in January 2018, she enrolled in a clinical trial, which has since led to a remarkable 40% reduction in tumor size.

• Clinical Trial Highlights:
  • Ongoing treatment covered by the drug company.
  • Significant tumor shrinkage and improved quality of life.

Allison’s emotional healing began as she processed her experiences and the possibility of a brighter future. She even celebrated her wedding in April, embracing life with newfound strength.

Embracing Life with Hope

Now, Allison is committed to sharing her story, hoping to inspire others facing similar battles. Her journey reminds us that while we may encounter unexpected exits in life, each can lead to new pathways filled with hope and resilience.

• Key Takeaways:
  • Importance of seeking second opinions.
  • The role of genetic testing in cancer treatment.
  • Finding strength in community and family support.

Allison Lippman Kuban’s story is a powerful reminder: take life one step at a time, and never underestimate the potential for hope and healing.