Revolutionary Alternating Protocols: A New Approach to Battling Pancreatic Cancer

Mark Fishman, a 71-year-old family practice physician, faced a life-altering diagnosis in March 2016 when he learned he had stage IV pancreatic cancer. After experiencing jaundice and a blockage in his bile duct, further tests revealed multiple liver metastases. A trusted colleague recommended Dr. Vincent Picozzi, an expert in this challenging field, at the Virginia Mason Medical Center in Seattle, marking the beginning of a unique treatment journey.

A Distinctive Treatment Protocol

Upon consultation, Dr. Picozzi suggested an intriguing approach known as the Seena Protocol. This regimen alternates two distinct treatment phases every eight weeks:

• First Treatment Arm: Involves a weekly infusion of gemcitabine and Abraxane for three consecutive weeks, followed by a rest week. This cycle is then repeated for an additional four weeks.
• Second Treatment Arm: Following the initial phase, the second arm includes dexamethasone to mitigate inflammation, along with an infusion of leucovorin and irinotecan. Patients then utilize a take-home pump delivering 5-FU for two days. Additional medications such as ondansetron and more dexamethasone are taken to manage side effects during this period.

Managing Side Effects and Monitoring Progress

Mark has adhered to this treatment regimen for nearly a year, with regular CT scans to monitor the status of his liver lesions. He has noted both short-term side effects and his overall resilience:

• Treatment Arm 1 Effects: Experiences significant fatigue on the first treatment day, likely due to the anti-anxiety medications.
• Treatment Arm 2 Effects: Faces some heartburn and constipation lasting about a week. Remarkably, he has managed to maintain a work schedule of four days a week throughout his treatment.

Despite the challenges, Mark has reported minimal long-term side effects, with mild peripheral neuropathy being the most significant. Prior to his diagnosis, he was an active individual, working out five times a week, but now exercises three to four times weekly.

Remarkable Progress in Health Metrics

Initially, Mark’s CA19-9 cancer marker was a staggering 139,000. However, his latest results showed a marked improvement, with the marker dropping to 172. Furthermore, his recent scans revealed only four liver metastases, all too small to be measured accurately.

To support his health during treatment, Mark has adhered to a comprehensive regimen of vitamins and supplements, which he believes has helped alleviate side effects. After stepping away from his practice in October 2016, he transitioned to a physician role in a medically supervised weight loss program in Bellevue, Washington.

Mark’s courage in exploring unconventional treatment options has not only extended his life but may also serve as an inspiration for others battling similar diagnoses.

A Legacy of Hope

Sadly, more than four years after his diagnosis, Mark passed away, leaving behind a legacy of resilience and hope. He exemplified the spirit of exploring innovative treatments for better outcomes.

For others seeking personalized treatment options, Dr. Stephen Bigelsen is another pancreatic cancer patient on a tailored regimen. Discover more about his journey and treatment experiences here.

Explore New Treatment Options

If you’re navigating pancreatic cancer, you might wonder about the latest treatments and clinical trials available. To learn more, visit our resource page here.

Mark’s story is a powerful reminder of the strength found in community, innovation, and the relentless pursuit of hope in the face of adversity.